Physical Simulated Y-Site Compatibility of Hypertonic Saline with Vasoactive Medications Commonly Used in Pediatric Intensive Care

Clicks: 14
ID: 333335
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #213 of 247 articles by views in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 247 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Purpose Critically ill pediatric patients often receive multiple IV medications concurrently. Due to limited vascular access in these patients, there is frequent Y-site coadministration. Incompatibility of medications can result in particulate formation, which poses serious clinical risks such as microvascular obstruction and organ dysfunction. This study aims to evaluate the Y-site compatibility of vasoactive medications with 12% hypertonic saline. Methods This study simulated Y-site compatibility of 12% hypertonic saline by preparing 1:1 mixing ratios of commonly used medications in pediatric concentrations. Medications that were analyzed included epinephrine, dopamine, norepinephrine, vasopressin, milrinone, alprostadil, and sildenafil. Analysis was completed using visual inspection, pH testing at 0 and 4 hours, and light obscuration to determine particulate counts. Particulate counts were assessed at ≥10 µm and ≥25 µm. Compatibility was defined using USP <788> thresholds. Results Of the seven vasoactive medications analyzed in combined with hypertonic saline, six met established compatibility criteria. The range of pH changes among all medications was –0.06 to +0.16, indicating stability over time and limited risk of meaningful acid-base alterations. Sildenafil was the only combination tested that demonstrated incompatibility with 12% hypertonic saline. Conclusion This report evaluated the compatibility of vasoactive medications at specific pediatric concentrations with 12% hypertonic saline, demonstrating incompatibility with only sildenafil 0.8 mg/mL. Epinephrine 100 mcg/mL, dopamine in D5W 3.2 mg/mL, alprostadil in D5W 20 mcg/mL, vasopressin in D5W 1 unit/mL, milrinone in D5W 200 mcg/mL, and norepinephrine 32 mcg/mL were all compatible with 12% hypertonic saline.
Reference Key
openalex_W7223183636 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Marissa Roccanova, Delaney Rugan, Anna B O'Brien, Emma L. Ross
Are you one of these authors? Claim your profile
Journal American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Year 2026
DOI
10.1093/ajhp/zxag351
URL
https://doi.org/10.1093/ajhp/zxag351
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.