Disseminated Nontuberculous Mycobacterial Disease in NEMO and Iκbα Defects

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ID: 333200
2026
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Abstract
Abstract Disseminated nontuberculous mycobacterial disease is a severe complication of NEMO (IKBKG) and IκBα (NFKBIA) defects. It may present in adulthood, and diagnosis was often delayed. Despite intensive multidrug therapy and adjunctive IFN-γ, treatment responses were frequently inadequate. Hematopoietic cell transplantation may offer immune reconstitution but carries risks.
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Authors Chen Wang, Amanda Elias Rivera, David Erwin Kleiner, Chi A. Ma, Mark T. Vander Lugt, John J. Lipuma, Alyssa R. Letourneau, Janine R. Daub, Anahita Agharahimi, Annalie J Harris, Lavenda Chirombo Kluczynski, Lindsey B. Rosen, Howard M. Lederman, M. Elizabeth M. Younger, Elias T. Zambidis, Maura M. Manion, Luxin Pei, Irini Sereti, Morgan N. Similuk, Danielle Fink, Debra A. Long Priel, John I. Gallin, Douglas Byron Kuhns, Adrian M. Zelazny, Gülbû Uzel, Amy P. Hsu, Christa S. Zerbe, Alexandra F. Freeman, Steven M. Holland
Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag602
URL
https://doi.org/10.1093/cid/ciag602
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