The Synaptic Basis of Memory

Clicks: 10
ID: 333077
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #1,580 of 1,787 articles by views in Oxford University Press eBooks

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,787 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Memory formation has long been studied as a consequence of activity-dependent synaptic plasticity; however, the precise neural substrate underlying memory storage remains a fundamental question in neuroscience. Traditionally, memory storage has been investigated from both cellular and synaptic perspectives. Neurons activated during learning, known as memory engram cells, are thought to encode memories through experience-dependent changes in synaptic strength and connectivity. Recent advances have extended this framework by revealing that memory storage depends not only on the recruitment of engram cells but also on the selective allocation and modification of synaptic connections between them, giving rise to the concept of engram synapses. This chapter reviews current understanding of the role of synaptic plasticity in memory formation, with particular emphasis on the molecular, structural, and functional mechanisms that shape memory consolidation. The chapter also discusses emerging evidence supporting engram synapses as a critical substrate of long-term memory storage. Together, these advances provide a framework linking engram cells and engram synapses, offering new insights into how the brain transforms transient experiences into enduring memories.
Reference Key
openalex_W7223036106 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Binod Timalsina, Bong‐Kiun Kaang
Are you one of these authors? Claim your profile
Journal Oxford University Press eBooks
Year 2026
DOI
10.1093/oxfordhb/9780190069162.013.0023
URL
https://doi.org/10.1093/oxfordhb/9780190069162.013.0023
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.