Markers of conceptus development reveal reduced developmental competence in pregnancies derived from lower SCR bulls

Clicks: 15
ID: 332876
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #153 of 188 articles by views in biology of reproduction

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 188 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Differences in fertility among bulls are well documented in the field, yet the understanding of the male contributions to in vivo embryonic development and pregnancy outcomes remains ill-defined. This study aimed to evaluate the effect of sire fertility, based on sire conception rate (SCR), on the timing of pregnancy loss and markers of conceptus developmental capacity in vivo. Angus cows were artificially inseminated with semen from Holstein sires classified as HighSCR (n = 55) or LowSCR (n = 104). Day 0 (d0) was defined as the day of AI. Cervical cells were collected on d3, 14, 16, 18, and 20 to assess ISG15 mRNA abundance, and blood was collected on d3 and daily from d14 to d31 to determine progesterone and pregnancy-associated glycoproteins (PAG). Pregnancy outcomes were defined using ISG15 (d14), PAG (d23), and ultrasonography (d31). Pregnancy per AI was greater for HighSCR than LowSCR on d14 (96.4% vs 85.6%; P = 0.05), d23 (81.8% vs 61.5%; P = 0.01), and d31 (69.1% vs 50.0%; P = 0.02). Embryos derived from LowSCR had reduced developmental competence as evidenced by lower ISG15 abundance compared to HighSCR (42.3 ± 4.4 vs 61.6 ± 7.9; P = 0.04) and three-fold greater pregnancy loss particularly when trophoblast differentiation and attachment occurred on ≥d21. Additionally, pregnancy loss prior to d24 was most often (95%) associated with embryonic failure and luteal regression whereas pregnancy loss after d23 most often associated with conceptus failure without luteal regression (85%).
Reference Key
openalex_W7222926948 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Florentino P J da-Silva-Junior, Paulo Mielli Bonacim, E. G. Kidwell, Lillian X Ehresmann, Bo R Harstine, Rafael Reis Domingues
Are you one of these authors? Claim your profile
Journal biology of reproduction
Year 2026
DOI
10.1093/biolre/ioag233
URL
https://doi.org/10.1093/biolre/ioag233
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.