Yandangshan Dendrobium officinale flower flavonoids alleviate dextran sulfate sodium (DSS)-induced colitis in association with local intestinal ecological remodeling

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ID: 332662
2026
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Abstract
Abstract Objectives Ulcerative colitis arises from epithelial barrier disruption, gut microbial dysbiosis, and aberrant mucosal immune activation. Given that many food-derived flavonoids achieve limited systemic exposure after oral administration, how local intestinal activity translates into host tissue protection remains a central question. Resolving this process is challenging because microbial communities, metabolite outputs, and mucosal responses operate across distinct biological levels and often yield disconnected evidence. Materials and Methods : Here, we studied chemically consistent Dendrobium officinale flower flavonoids (DOFF), validated across six independent batches by liquid chromatography-mass spectrometry (LC-MS), and integrated absorption, distribution, metabolism, and excretion (ADME) prediction, conventional and antibiotic-perturbed dextran sulfate sodium (DSS) colitis models, 16S rRNA sequencing, targeted short-chain fatty acid quantification, untargeted fecal metabolomics, host-response network analysis, single-cell virtual knockout, and whole-slide artificial intelligence (AI)-assisted spatial pathology. Results DOFF reduced dextran sulfate sodium-induced disease activity and colonic injury, restored ZO-1- and Occludin-associated barrier integrity, reconfigured gut microbial structure and fecal metabolic profiles, and suppressed TLR4/MYD88/NF-κB signaling; computational integration and single-cell virtual knockout further prioritized FFAR2/HCAR2, TLR4/RELA, and EGFR/LGR5 as candidate host targets associated with metabolite sensing, inflammatory regulation, and epithelial repair, respectively, while DOFF retained partial tissue protection after broad-spectrum antibiotic perturbation, accompanied by limited shifts in residual microbiota and AI-predicted spatial pathology features. Conclusions These findings support a local ecology-first working model in which DOFF-associated microbiota-metabolite remodeling coincides with epithelial barrier restoration and mucosal inflammatory suppression without necessarily requiring high systemic exposure or action through a single host target, although direct causal roles for the microbiota, key metabolites, and host receptors require further validation.
Reference Key
openalex_W7222814176 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xiang-Dong Wang, Yujiao Zhang, Jiahao Pan, Rong Huang, Jinou Lin, Xiaodan Zhang, Bolu Sun, Xiaojie Zheng
Journal Food Quality and Safety
Year 2026
DOI
10.1093/fqsafe/fyag086
URL
https://doi.org/10.1093/fqsafe/fyag086
Keywords Keywords not found

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