Injectable Zwitterionic Hydrogels Formed through Dynamic Boroxole–Carbohydrate Crosslinking for Protein Encapsulation

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ID: 332634
2026
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Ranked #810 of 811 articles by views in phytochemistry letters

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Abstract
Abstract We developed an injectable zwitterionic hydrogel from 2-methacryloyloxyethyl phosphorylcholine-based copolymers bearing lactobionamide or benzoxaborole units through reversible boroxole–carbohydrate crosslinking. The hydrogel exhibited frequency-dependent viscoelasticity and could be readily extruded through a syringe needle. Encapsulated alkaline phosphatase in the hydrogel retained approximately 95% of its activity after syringe extrusion and subsequent recovery, demonstrating the potential of the dynamic hydrogel as a reversible matrix for protein encapsulation and processing.
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Authors Armeida D. R. Madjid, Masanori Nagao, Katsuhiro Kaetsu, Hikaru Matsumoto, Ravin Narain, Yoshiko Miura
Journal phytochemistry letters
Year 2026
DOI
10.1093/chemle/upag202
URL
https://doi.org/10.1093/chemle/upag202
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