An eight-ketohexose stereoisomer screen identifies d -allulose as a stereoselective suppressor of AGE-related autofluorescence in Caenorhabditis elegans

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ID: 332595
2026
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Abstract
Advanced glycation end products (AGEs) accumulate with age and contribute to age-related disease. Using an autofluorescence assay in Caenorhabditis elegans, we screened all eight ketohexose stereoisomers. The response was highly stereoselective: only d-allulose significantly suppressed autofluorescence (∼22% at 10 mM and ∼20% at 25 mM; corrected p < 0.01), while its enantiomer l-allulose, assayed alongside it, had no detectable effect. The suppression was undetectable at 5 mM and did not deepen between 10 and 25 mM, and suppression was also detected at 25 mM with killed bacteria. Despite this in vivo suppression, d-allulose generated substantial glycation-associated fluorescence in a cell-free bovine serum albumin system at 60 °C, indicating that it is not chemically inert. These results establish a stereochemical activity map of ketohexoses toward AGE-related autofluorescence.
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openalex_W7222616943 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Masashi Sato, Keiko HIRATA, Hiromu Takagishi, Kanon Hosokawa, Yuka Fukushima, Tomoya Shintani
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag156
URL
https://doi.org/10.1093/bbb/zbag156
Keywords Keywords not found

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