Iron electronic delocalization enables catalytic selective trisilyla-tion: beyond steric hindrance

Clicks: 25
ID: 332586
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #98 of 421 articles by views in national science review

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 421 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract The efficient synthesis of sterically congested tetrasubstituted alkenes, particularly the synthetically valuable 1,1,2-trisilylalkenes, remains a longstanding challenge due to significant steric hindrance encountered during the bond formation. Here, we report an iron-catalyzed trisilylation of ynamides that leverages iron electronic delocalization to modulate the character of double bonds toward that of single bonds, effectively mitigating steric constraints during the reaction. This strategy enables a regioselective and controllable synthesis of 1,1,2-trisilylated alkenes, trans-1,2-disilylated alkenes, and monosilylated alkynes under mild conditions with high efficiency. Notably, the method allows for late-stage functionalization of biologically relevant molecules, offering a valuable platform for the structural diversification of alkynes. In addition, the resulting multisilylated intermediates undergo diverse downstream transformations, granting access to a broad array of otherwise elusive tetrasubstituted silylalkenes. Experimental and computational studies reveal that monosilylalkynes serve as key intermediates, with β-N elimination, double migratory insertion, and reductive elimination steps likely involved in the catalytic cycle. This work provides fundamental insights into the construction of sterically hindered chemical bonds via base metal catalysis and underscores the potential of iron to unlock unconventional reactivity through electronic delocalization effects.
Reference Key
openalex_W7222518687 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Feihu Gou, Jingyao Chen, Hong Huang, Yanru Ji, Chaoqun Shi, Yun He, Hongdan Zhu, Qian Peng, Feng Zhang
Are you one of these authors? Claim your profile
Journal national science review
Year 2026
DOI
10.1093/nsr/nwag651
URL
https://doi.org/10.1093/nsr/nwag651
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.