An ADAR1 variant as a candidate modifier of cutaneous disease severity in familial psoriasis

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ID: 332140
2026
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Abstract
In a consanguineous three-generation family, psoriasis of variable severity segregated with rare IFNGR1 and ADAR1 variants on a shared HLA-C*12:03 background. These findings position the ADAR1 variant as a modifier of psoriasis severity rather than an independent monogenic cause.
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Authors Eylon Sharoni, Rawaa Ishtewy, May Arad, Lubna Gazi Khair, Shavit Kachlon, Yoni Moskovitz, Mor Pavlovsky, Nadav Astman, Ori Elkayam, Liat Samuelov, Eli Sprecher, Hagit Matz, Shir Azrielant
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Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag452
URL
https://doi.org/10.1093/bjd/ljag452
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