Inhibitory Activity on Dog Bladder Cancer Organoids by Lanostane-type Triterpenes from Inonotus obliquus and Reinvestigation of Their NMR Assignments

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ID: 332113
2026
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Abstract
Abstract Dog bladder cancer organoids (DBCO) serve as a model of human muscle-invasive bladder cancer (MIBC), for which suitable human organoid models remain limited. Inonotus obliquus (Chaga) extract reportedly reduces DBCO growth, but its active constituents were unidentified. We isolated four lanostane-type triterpenes from Chaga extract through fractionation guided by DBCO viability and revised their previous NMR assignments. All compounds reduced DBCO viability at 21.8 µM (10 µg/mL), with compound 3 showing the greatest potency, suggesting that C-21/C-24 stereochemistry may influence cytotoxicity.
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openalex_W7221512179 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wai Lam Tse, Mohamed Elbadawy, Haru Yamamoto, Ting Wei Yu, Tatsuya Usui, Kazuaki SASAKI, Yuta Shinohara, Fumiaki Nakamura, Koshi Machida, Yoichi Nakao
Journal phytochemistry letters
Year 2026
DOI
10.1093/chemle/upag198
URL
https://doi.org/10.1093/chemle/upag198
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