Visual Target P3b Amplitude Mediates the Relationship between Childhood Traumatic Experiences and Social Functioning in People at Clinical High Risk for Psychosis

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ID: 332101
2026
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Abstract
Abstract Background and Hypothesis Clinical high risk (CHR) for psychosis status is associated with poor social functioning. Previous studies suggest that childhood trauma and reduced amplitude of the P300 event-related potential (ERP) component elicited by infrequent target stimuli (P3b) are associated with poor social function. Here, we examined whether reduced P3b mediates the relationship between reported trauma history and social function in CHR individuals, possibly reflecting the impact of past trauma on neurophysiological processes subserving attention that ultimately influence social functioning. Study Design Target P3b ERP amplitudes from visual and auditory oddball tasks acquired at baseline in the Accelerating Medicines Partnership® Schizophrenia (AMP SCZ) study were analyzed. The mediating effects of auditory and visual P3b amplitude on the relationship between trauma history (Childhood Trauma Questionnaire total score) and Negative Symptom Inventory-Psychosis Risk Asociality (NSI-PR) as well as social functioning (Global Functioning: Social (GFS) scores were examined. Study Results Data from 931 CHR participants (average age 21.29 years, 36.3% male) were included in mediation analyses. Visual P3b showed significant (p < .05) mediation of the relationship between trauma load and GFS score (5.4% mediation) as well as mediation of the relationship between trauma history and NSI-PR asociality (9.3% mediation). Auditory P3b did not significantly mediate either relationship. Conclusions These results suggest that visual, but not auditory, P3b mediates the relationship between past trauma load and social functioning in CHR, suggesting the effect of trauma on the neurophysiological processes subserving visual target detection may contribute to social functioning deficits in CHR individuals.
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Authors Jason Smucny, Holly Hamilton, Suzie Lavoie, Thomas J. Whitford, Luis Alameda, Öznur Baştürk, Grace R. Jacobs, Inès Lepreux, Teya Petrova, Lotta-Katrin Pries, Guilia Trotta, Sandra Vieira, Jean Addington, Sylvain Bouix, Nicholas J K Breitborde, Matthew R. Broome, Kristin S. Cadenhead, Monica E. Calkins, Ricardo E. Carrión, Rolando I Castillo-Passi, Jimmy Choi, Philippe Conus, Cheryl Mary Corcoran, Covadonga M. Díaz‐Caneja, Lauren M. Ellman, Paolo Fusar-Poli, Louise Birkedal Glenthøj, Leslie E. Horton, Joseph P. Kambeitz, Tina Kapur, Matcheri S. Keshavan, Minah Kim, Sung‐Wan Kim, Jun Soo Kwon, Daniel Mamah, Vijay Anand Mittal, Ofer Pasternak, Godfrey D. Pearlson, Jesus Perez, David R. Roalf, Jason Schiffman, Jai L. Shah, Steven M. Silverstein, Stefan Smesny, Gregory P. Strauss, Judy L. Thompson, Daniel H. Wolf, Tianhong Zhang, Carrie E. Bearden, John Michael Kane, René S Kahn, Patrick D. McGorry, Barnaby Nelson, Martha E. Shenton, Scott W Woods, Gregory A Light, Daniel H. Mathalon
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Journal Schizophrenia Bulletin Open
Year 2026
DOI
10.1093/schizbullopen/sgag041
URL
https://doi.org/10.1093/schizbullopen/sgag041
Keywords Keywords not found

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