Arsenic-sensing domain controls ACR3 transporter trafficking in Marchantia polymorpha

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ID: 331715
2026
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Abstract
Abstract Arsenic is a toxic, carcinogenic metalloid that threatens human health through contaminated water and food. Arsenite [As(III)] efflux mediated by ACR3 transporters is an ancient detoxification mechanism conserved across prokaryotes, fungi, algae, and non-angiosperm land plants, yet plant ACR3 proteins remain poorly characterized. Here, we show that MpACR3, the ACR3 ortholog from the model liverwort Marchantia polymorpha, contains an arsenic-responsive N-terminal domain that regulates intracellular trafficking. Under non-stress conditions, MpACR3 is detected in Golgi bodies as well as at the plasma membrane in plant cells, whereas As(III) promotes its relocalization to the plasma membrane. As(III) interacts with a cysteine-rich N-terminal region and stabilizes this domain, as shown by arsenite-biotin competition and increased protease resistance. Together with molecular dynamics simulations, which predicts As(III)-dependent changes in secondary structure and surface properties, these findings support a model in which ligand-induced remodeling of the N terminus modulates MpACR3 retention and trafficking. We further identify a di-arginine-containing LRCRF motif in which leucine and arginine residues are required for intracellular retention, whereas cysteine and phenylalanine residues are required for As(III)-induced relocalization to the plasma membrane. The broad conservation of related N-terminal domains in plant ACR3 transporters suggests that arsenic-regulated trafficking is a conserved plant adaptation to arsenic toxicity.
Reference Key
openalex_W7220832310 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ignacy Bonter, Katarzyna Mizio, Alicja Dołzbłasz, Paulina Tomaszewska, Kacper Zbieralski, Jacek Staszewski, Donata Wawrzycka, Anna Reymer, Wojciech Białek, Verena Kriechbaumer, Jim Haseloff, Robert Wysocki, Ewa Maciaszczyk-Dziubińska
Journal The Plant cell
Year 2026
DOI
10.1093/plcell/koag306
URL
https://doi.org/10.1093/plcell/koag306
Keywords Keywords not found

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