Magnetic decantation-enabled pot- and time-economical liquid-phase peptide synthesis

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ID: 331569
2026
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Abstract
Soluble support (tag)-assisted liquid-phase peptide synthesis (LPPS) is a greener alternative to solid-phase peptide synthesis (SPPS) because it reduces the consumption of reagents and solvents throughout the synthetic process. In conventional LPPS, tagged peptides are selectively precipitated and isolated by filtration; however, filtration can be time-consuming depending on the physical properties of the precipitate. Herein, we report a magnetic decantation-enabled, filtration-free LPPS protocol using chemically stable and reversibly dispersible hydrophobic magnetic nanoparticles. Magnetic decantation performed after each coupling/deprotection sequence enables pot- and time-economical peptide synthesis without filtration. The feasibility of the protocol was demonstrated through the synthesis of leucine-enkephalin as a model peptide, affording the target peptide in excellent yield and high purity without chromatographic purification.
Reference Key
openalex_W7220702572 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jun Karasawa, Tatsuya Sudo, Shohei Yamashita, Yoshikazu Kitano, Yohei Okada
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag149
URL
https://doi.org/10.1093/bbb/zbag149
Keywords Keywords not found

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