Taxon-specific oral mycobiome differences and bacterial–fungal associations in kidney transplant recipients and donors

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ID: 331556
2026
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Abstract
AIMS: This study characterised the pre-transplant salivary mycobiome of kidney transplant recipients and living donors and investigated cross-kingdom associations with the bacteriome. METHODS AND RESULTS: Mycobiome profiling was performed using ITS sequencing of donor and recipient samples, while paired bacteriome data were obtained from our previous study. No significant differences in fungal or bacterial alpha diversity or beta diversity were detected between recipients and donors, indicating an absence of broad community-level separation. Malassezia and Candida were the dominant fungal genera in both groups. Differential abundance analyses using ANCOM-BC2 and DESeq2 consistently identified lower Malassezia abundance in recipients, alongside predominantly lower abundance of several bacterial taxa. Cross-kingdom network analysis showed low Jaccard similarity in highly central taxa between donors and recipients, despite no significant differences in global network properties. This pattern persisted across most sample-size-matched subsamples. CONCLUSIONS: These findings suggest that oral microbiome differences between kidney transplant recipients and donors are more apparent in specific taxonomic changes, particularly the reduction in Malassezia, and in the relative organisation of central community members than in broad shifts in overall microbial composition.
Reference Key
openalex_W7220674137 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors E Cihan, Paul M. Campbell, Yuhan Wu, Ruth G. Ledder, Angela M Summers, Titus Augustine, Christopher G. Knight, Andrew J. McBain
Journal Journal of applied microbiology
Year 2026
DOI
10.1093/jambio/lxag247
URL
https://doi.org/10.1093/jambio/lxag247
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