PS2-3. β-defensins Gene Expression in Nasal Mucosal Secretions of Calves with Bovine Respiratory Disease by Elevated Body Temperature.

Clicks: 13
ID: 330456
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #479 of 847 articles by views in italian journal of animal science

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 847 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Bovine respiratory disease (BRD) is the most economically significant disease in the U.S. cattle industry, resulting in greater financial losses than any other illness. Although vaccination and antibiotic treatments are commonly used, they are not always effective due to the variety of BRD-causing pathogens, and excessive antibiotic use may contribute to antibiotic resistance. Therefore, alternative approaches that focus on microbial and immune system mechanisms may provide more effective strategies for reducing BRD. Defensins are antimicrobial proteins produced during the innate immune response, and β-defensins are secreted by mucosal epithelial cells in tissues. The objective of this study was to determine β-defensin expression in nasal mucosal secretions of calves affected by BRD. Post-weaned crossbred beef calves (n = 9; average BW 278.1 ± 36 kg) were evaluated for mucosal β-defensin expression. Nasal swabs and rectal temperatures were collected on d 0, 1, 2, and 3 at 0800 h. Rectal temperature was used to assign BRD status each day where ‘sick’ calves had a rectal temperate ≥ 39.4 °C while ‘healthy’ had a rectal temperature < 39.4 °C. Relative expression of β-defensins DEFB401, DEFB402, and DEFB403 from nasal swabs was determined using qPCR and calculated using the 2-ΔΔCt method. Data were analyzed using the GLIMMIX procedure of SAS. Significance was declared at P ≤ 0.05. β-defensin expression in nasal mucosal secretions did not differ between healthy and sick calves. More specifically, there was no effect of BRD status on expression of DEFB401 (P = 0.63), DEFB402 (P = 0.34), or DEFB403 (P = 0.92). These results suggest that the β-defensins measured in the current study do not differ between calves diagnosed with BRD based on elevated rectal temperature. Therefore, future research is warranted to understand the mechanisms of DEFB 401, 402, and 403 defensins as well as identifying additional β-defensins that might interact with innate host immunity against BRD.
Reference Key
openalex_W7214756883 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ariana Evans, Olivia S Brummett, Vivian Barrera, Lanie Dela Rosa, Brian L Bruner, Michael B Sims, Reagan N Sims, Sami Dridi, Elizabeth S. Greene, Cesar Augusto Rosales-Nieto
Are you one of these authors? Claim your profile
Journal italian journal of animal science
Year 2026
DOI
10.1093/jas/skag272.545
URL
https://doi.org/10.1093/jas/skag272.545
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.