PS11-2. Characterizing Metabolic Gradients in Bovine Liver Tissue Across Abscess Proximity.

Clicks: 10
ID: 330239
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #783 of 847 articles by views in italian journal of animal science

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 847 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract The liver serves as the central hub of metabolic processes within the animal body. Bovine liver abscesses are theorized to impact metabolism and absorption of nutrients. This study aimed to determine if metabolic alterations occur in liver tissue located at varying distances between abscesses. Bovine livers (n = 20) were collected from a commercial harvest facility, and core samples were collected from tissue positioned at varying distances (1.27 to 7.83 cm) approximately equidistant between three abscesses. Untargeted primary metabolites were profiled using gas chromatography-mass spectrometry. A generalized additive model with spline smoothing was used to evaluate metabolite abundance and capture linear and non-linear spatial relationships across a distance gradient. Metabolites associated with carbohydrate metabolism (lactose-2, maltotriose, and melezitose) and oxidative energy-production (citric acid) increased (P £ 0.02) in a non-linear concentration with increasing distance from an abscess. This is suggestive of a shift from a pathogen-dominated, metabolically suppressed environment proximal to an abscess towards more physiologically normal metabolism in healthy liver tissue. A linear decrease (P £ 0.05) in metabolite concentration was observed for 2-aminobutyric acid, asparagine, cholesterone, citrulline, cyanoalanine, threonine, and valine. These metabolites indicate that bacterial metabolism adjacent to an abscess creates a shift into anaerobic pathways and tissue breakdown. Other metabolites (creatinine, lactic acid, phenylalanine, threonic acid, xanthine) exhibited subtle non-linear concentration reductions as distance from an abscess increased. Anaerobic metabolic changes are indicated through the drop in lactic acid levels at further distances from an abscess, which could indicate a normalization in liver tissue and aerobic glycolysis. A decrease in creatinine levels can indicate a decrease in protein breakdown as distance increases from an abscess. Oxidative stress was also observed to decrease further away from a liver abscess through the decrease of phenylalanine and threonic acid. In summary, liver tissue metabolites were indicative of tissue stress changes, inflammation, and liver failure signals. These data confirm a change in liver metabolism and oxidative stress levels, likely indicative of change in metabolic liver function associated with active liver abscesses.
Reference Key
openalex_W7214722662 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Macy T Lawrence, Joe D Roder, Trent E Schwartz, Loni W Lucherk, T.E. Lawrence, Emilie C. Baker
Are you one of these authors? Claim your profile
Journal italian journal of animal science
Year 2026
DOI
10.1093/jas/skag272.338
URL
https://doi.org/10.1093/jas/skag272.338
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.