PS7-9. Increase in Markers of Systemic Inflammation in Canines and Subsequent Mortality Risk.

Clicks: 10
ID: 330162
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #774 of 847 articles by views in italian journal of animal science

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 847 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Systemic inflammatory blood biomarkers involving lymphocytes are reliable indicators of changes in immune function. In this study, we evaluated the Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Systemic Immune-Inflammation Index (SII) from standard CBC in canines. These ratios are indicators of chronic inflammation and an increase in values have been associated with inflammation and poor prognosis in selected adverse health conditions. Chronic low-grade inflammation is a key feature in aging dogs. In this study we analyzed a minimum of eight years of complete blood count (CBC) data from 107 aging dogs housed at the Hill’s Pet Nutrition Center. Ratios were calculated longitudinally based on time-to-mortality or natural end-of-life intervals (0–6 months, >6 months–1.5 years, >1.5–3 years, and >3 years preceding death). Furthermore, the data were evaluated by binning the subjects into three age groups: 1–6 years, 6–11 years, and >11 years. Data are presented as Mean + SEM and Tukey’s post-hoc test for multiple comparisons. Mean age at death was 14.1+1.5 years. NLR, PLR and SII all increased as dogs neared the end-of-life (EOL). NLR was significantly increased in dogs that were 11 years or older (3.5+0.1) when compared to dogs in age groups of 1-6 years (2.7+0.1) and 6-11 years (2.9+0.1, both p < 0.05). When compared across age groups, there was a progressive increase in PLR as the animals aged: 1-6 years (180+5.40); 6-11 years (235+4.5), and >11 years (324+7.4; all p < 0.05 between groups). The increase in SII was more pronounced within 6 months of EOL when compared to 3 years from EOL (1959+102, vs 756+14.2, p < 0.05). In summary, NLR, PLR, and SII are accessible biomarkers of age-related systemic inflammation. SII and PLR increased significantly as dogs aged and approached the natural EOL. Together, these markers offer clinical insights for monitoring systemic inflammation in aging. Establishing reference intervals will be useful for prognosis as well as developing targeted nutritional strategies for chronic low-grade inflammation in selected health conditions in canines.
Reference Key
openalex_W7214712327 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Regina L. Hollar, Kiran S. Panickar
Are you one of these authors? Claim your profile
Journal italian journal of animal science
Year 2026
DOI
10.1093/jas/skag272.462
URL
https://doi.org/10.1093/jas/skag272.462
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.