185. Influence of Ruminal or Postruminal 5-hydroxytryptophan Administration on Serotonin Metabolism and Arterial Hemodynamics in Growing Beef Steers.

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ID: 330095
2026
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Abstract
Abstract Serotonin is synthesized from tryptophan through hydroxylation and decarboxylation reactions, with 5-hydroxytryptophan (5-HTP) serving as the immediate precursor. Because 5-HTP bypasses the rate-limiting step of serotonin synthesis, it has been used to experimentally increase circulating serotonin in ruminants via enteral or intravenous administration; however, the capability of ruminally-supplied 5-HTP to escape microbial degradation and influence peripheral serotonin metabolism and vascular function has not been fully characterized. The objective of this study was to evaluate ruminal or postruminal 5-HTP administration on peripheral serotonin metabolism and caudal artery hemodynamics in growing beef steers. Five ruminally cannulated Angus × Holstein steers [body weight (BW) = 284 ± 10.6 kg] were randomly assigned to a 5 × 5 Latin square design and limit-fed an alfalfa cube diet. Treatments consisted of water (negative control), abomasal infusion of 0.5 mg 5-HTP/kg BW (positive control), or ruminal infusions of 1, 2, or 3 mg 5-HTP/kg BW administered as daily pulse doses for 5 d, with 5-d washout periods. Blood samples were collected serially over 24 h on days 1 and 5 of each period for analysis of tryptophan, kynurenine, 5-HTP, serotonin, and 5-hydroxyindolacetic acid. Caudal artery hemodynamics were assessed using color Doppler ultrasonography. Dry matter intake and plasma biomarkers of energy and protein metabolism were not affected (P ≥ 0.15) by enteral 5-HTP treatments. Abomasal 5-HTP infusion rapidly increased (P < 0.05) serum 5-HTP and increased serum serotonin concentration on day 5 (P < 0.05). Increasing ruminal 5-HTP infusion increased serum serotonin concentration in a dose-dependent manner, indicating partial escape from ruminal degradation and effective postruminal utilization. Relative to baseline, ruminal infusion of 3 mg 5-HTP/kg BW increased caudal artery cross-sectional area (P < 0.05), demonstrating peripheral vasodilation, whereas lower ruminal 5-HTP doses and abomasal 5-HTP infusion did not elicit measurable vascular responses. These results demonstrate that ruminal 5-HTP administration can increase circulating serotonin and, at sufficient doses, ruminal 5-HTP administration promotes peripheral vasodilation. This study provides the first in vivo evidence of arterial vasodilation associated with 5-HTP supplementation in cattle and establishes ruminal delivery as a viable route for modulating serotonergic and vascular function.
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Authors Ellem M. A. Matos, David Lee Harmon, Brittany E Davis, Ronald J Trotta
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Journal italian journal of animal science
Year 2026
DOI
10.1093/jas/skag272.271
URL
https://doi.org/10.1093/jas/skag272.271
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