PS4-21. Serum Metabolomic Changes Induced by Guanidinoacetic Acid Supplementation in Growing Nellore Cattle.

Clicks: 13
ID: 330093
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #424 of 847 articles by views in italian journal of animal science

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 847 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Guanidinoacetic acid (GAA) is a fundamental precursor of creatine, and its role in muscle energy metabolism is of potential importance in growing cattle. The objective was to evaluate blood metabolic changes induced by GAA supplementation in Nellore cattle during the growing phase. The experimental lasted 280 days and during this phase, 51 recently weaned Nellore cattle (initial body weight [BW] of 265 ± 19 kg and age of 8 ± 2 months) were used. Animals were blocked by BW and randomly allocated to paddocks and assigned to four treatments: a control treatment without GAA supplementation (CON), and treatments supplemented with 3, 6, and 9 g·kg-1 of dry matter (DM) of GAA (GAA3, GAA6, and GAA9, respectively). Throughout the experimental period, animals received a protein-energy supplement at 3 g·kg-1 of BW daily, with or without GAA inclusion. At the end of the growing phase, blood samples were collected, centrifuged, filtered (3 kDa; 10,000 g, 30 minutes, 4 °C) to obtain serum for metabolomic analysis by nuclear magnetic resonance (¹H-NMR). Univariate statistical analyses were performed independently for each metabolite using linear models to evaluate treatment effects in an exploratory approach. The following pairwise comparisons were performed: CON × GAA3, CON × GAA6, and CON × GAA9. The ¹H-NMR analysis identified 48 metabolites common to all experimental groups during the growing phase. Supplementation with GAA3 resulted in greater concentrations of phosphocreatine (P = 0.042), glutamate (P = 0.001), glycine (P = 0.024), proline (P = 0.025), and uridine (P = 0.042) compared with the control group. In addition, dimethyl sulfone (P = 0.073), lysine (P = 0.081), succinate (P = 0.074), taurine (P = 0.069), and tyrosine (P = 0.088) showed increasing trends in the GAA3 group. Phosphocreatine remained elevated in the GAA6 group compared with the control (P = 0.046). Increases were also observed for glutamate (P = 0.013), proline (P = 0.001), and succinate (P = 0.006). Creatine showed a tendency toward higher concentration in the control group (P = 0.051), whereas isoleucine showed a tendency to increase in the supplemented group (P = 0.077). Animals receiving GAA9 presented greater concentrations of asparagine (P = 0.045) and glutamate (P = 0.040) compared with the control group. Conversely, glycerol concentration was lower in the GAA-supplemented groups (P = 0.039). Dimethyl sulfone (P = 0.055) and uridine (P = 0.053) showed increasing trends in GAA9, while ornithine tended to be greater in the control group (P = 0.092). Based on the results of this study, guanidinoacetic acid supplementation in growing Nellore bulls modulated energy and protein metabolism, as evidenced by changes in metabolite abundance compared to the control group.
Reference Key
openalex_W7214700770 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Letícia Carolina Bortolanza Soares, Leticia K Kim Huang, Germán Darío Ramírez-Zamudio, Maria Eduarda Ramos, Fabiana Ayumi Shiozaki, Valéria Oliveira Valente Araújo, Erly Sofía Castañeda Jiménez, Brenda Santos de Oliveira, Eduardo Solano Pina dos Santos, Carl Robertson R Dahlen, Nara Regina Brandão Cônsolo, Saulo da Luz Silva, Paulo Roberto Leme
Are you one of these authors? Claim your profile
Journal italian journal of animal science
Year 2026
DOI
10.1093/jas/skag272.624
URL
https://doi.org/10.1093/jas/skag272.624
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.