Next-generation brain organoids: neural complexity from cellular diversity to functional networks

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ID: 330067
2026
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Abstract
Brain organoids, as pioneering three-dimensional (3D) in vitro platforms, have profoundly advanced our understanding of human brain development and disease mechanisms. This review summarizes recent progress in enhancing cellular diversity, structural organization, and functional complexity within brain organoids. A key application of these models lies in disease modelling, encompassing neurodevelopmental and neurodegenerative disorders as well as brain tumours, which enables personalized drug screening and mechanistic studies. Despite persistent challenges related to neuronal maturation, vascularization, reproducibility, and functional integration, we highlight emerging bioengineering strategies, multi-organ integration approaches, and ethical considerations that provide a roadmap for next-generation organoid platforms. Collectively, brain organoids hold transformative potential for both fundamental neuroscience and translational research, bridging critical gaps between conventional experimental models and human-specific pathophysiology.
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openalex_W7214660896 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chun-Hui Duan, Yu-Kai Wang, Tie-Shan Tang, Jianwei Jiao, Yi Tang, Zhao‐Qian Teng, Baoyang Hu, Chang‐Mei Liu
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Journal Brain research
Year 2026
DOI
10.1093/brain/awag332
URL
https://doi.org/10.1093/brain/awag332
Keywords Keywords not found

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