Unmet Needs in the Management of Adult Patients with Lupus Nephritis
Clicks: 12
ID: 329926
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
3.0
/100
12 views
10 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #102 of 119 articles by views in nephrology dialysis transplantation
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Lupus nephritis is a major cause of morbidity and long-term kidney damage in patients with systemic lupus erythematosus. Despite therapeutic advances, complete remission rates remain modest, and progress to kidney failure still occurs in a substantial proportion of patients. Contemporary management has shifted toward early initiation of ‘triple therapy’, yet patients continue to suffer from the adverse effects of prolonged glucocorticoid exposure. Challenges persist, including treatment duration, safe tapering, and the high rates of flare following immunosuppression withdrawal, underscoring the potential role of repeat kidney biopsy in guiding decisions. Poor adherence is very common and a significant impediment in daily practice and often leads to the incorrect classification of patients as having ‘refractory disease’. Furthermore, conventional biomarkers are not ideal for flare prediction. Emerging therapies offer promising efficacy but remain inaccessible for many patients due to high costs and different reimbursement policies. Comprehensive management further requires attention to pregnancy planning, infection prophylaxis, care of chronic kidney disease, and long-term complications such as malignancy and osteoporosis. The goal should be to preserve kidney function, minimize cumulative toxicity, and restore quality of life to all patients, regardless of geography or economic status. This article provides a perspective of the Immunonephrology Working Group (IWG) of the European Renal Association (ERA) and discusses the key unmet needs in the management of lupus nephritis.
| Reference Key |
openalex_W7214496378
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Şeyda Gül Özcan, Annette Bruchfeld, Fernando Caravaca‐Fontán, Sarah Margaret Moran, Stefanie Steiger, Kate Stevens, Y K Onno Teng, Eleni Frangou, Andreas Kronbichler, Luis Fernando Quintana, Şafak Mirioğlu |
| Journal | nephrology dialysis transplantation |
| Year | 2026 |
| DOI |
10.1093/ndt/gfag220
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.