FAIDR-Desi: interactive software for feature analysis and design of intrinsically disordered regions

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ID: 329820
2026
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Abstract
SUMMARY: FAIDR-Desi is a non-technical user interface for design of intrinsically disordered regions (IDRs) based on greedy optimization of sequence features (simple sequence statistics correlated with IDR function, including amino acid composition, residue patterning and short linear interaction motifs), using more features (127) than other IDR design approaches. FAIDR-Desi can be used to design synthetic IDR mimics to establish feature sufficiency for function, or to knock out features to show necessity for function, exemplified with experiments on the yeast Cox15 mitochondrial targeting signal. AVAILABILITY AND IMPLEMENTATION: Software is freely available on the web at https://moses-lab.github.io/faidr_desi/ and an archival version of the source code is available on Zenodo (https://doi.org/10.5281/zenodo.22036189). SUPPLEMENTARY INFORMATION: Supporting and supplementary information can be found on Zenodo (https://doi.org/10.5281/zenodo.22084467).
Reference Key
openalex_W7214346747 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tian Hao Huang, Robert Strome, Julie Forman-Kay, Alan M Moses
Journal BMC Bioinformatics
Year 2026
DOI
10.1093/bioinformatics/btag715
URL
https://doi.org/10.1093/bioinformatics/btag715
Keywords Keywords not found

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