The Muscle-Bone Unit in Children and Adolescents: Insights from the Canadian Health Measures Survey

Clicks: 12
ID: 329764
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #93 of 135 articles by views in journal of bone and mineral research : the official journal of the american society for bone and mineral research

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 135 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Muscle and bone are closely related during growth and development. We sought to identify determinants of the muscle-bone relationship using peripheral quantitative computed tomography (pQCT) at the distal lower extremity and jumping mechanography among Canadian children. Data were obtained from the Canadian Health Measures Survey (CHMS), a national, cross-sectional, population-based study. 3,225 participants (aged 6 to 19.9 years) were included. Calf muscle cross-sectional area (CSA; 66% site) z-score was used as a surrogate measure of muscle strength, bone mineral content (BMC) z-score of the tibia shaft cross-section (38% site) was used as a surrogate measure of bone strength. Maximum jumping power (Pmax) z-score from the single two-legged jump test was assessed as a mediator between muscle CSA and BMC z-scores using path analysis. Peripheral QCT and Pmax z-scores were calculated using CHMS data. Height, weight, and body mass index (BMI) z-scores were calculated using Centers for Disease Control reference data. We found a strong positive association between muscle CSA z-score and tibia BMC z-score (β = 0.64, 95% confidence interval [CI]: 0.62 to 0.67). Calf subcutaneous fat CSA (β = -0.04, 95% CI: -0.07 to -0.01) and muscle density (β = 0.08, 95% CI: 0.03 to 0.13) z-scores were weak determinants, and weight (β = 0.10, 95% CI: 0.05 to 0.15) and BMI (β = 0.14, 95% CI: 0.07 to 0.21) z-scores were strong determinants of the association between muscle CSA z-score and BMC z-score. Self-reported moderate-to-vigorous physical activity and serum total calcium, 25-hydroxy-vitamin D3, and parathyroid hormone were not determinants. Pmax z-score was a partial mediator of the association between muscle CSA and BMC z-scores. In conclusion, we found that the effect of muscle size on bone mass was in part mediated by muscle power. Subcutaneous fat, muscle density, weight, and BMI were determinants of the muscle-bone relationship.
Reference Key
openalex_W7214337679 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Oliver Li, Leanne Marie Ward, Lauren E. Griffith, Laura N. Anderson, Andy Kin On Wong, Jonathan D Adachi, Jinhui Ma, Frank Rauch
Journal journal of bone and mineral research : the official journal of the american society for bone and mineral research
Year 2026
DOI
10.1093/jbmr/zjag143
URL
https://doi.org/10.1093/jbmr/zjag143
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.