Current clues towards precision peritoneal dialysis

Clicks: 33
ID: 329749
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #36 of 228 articles by views in clinical kidney journal

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 228 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Peritoneal dialysis (PD) is a vital renal replacement therapy for end-stage renal disease (ESRD), yet its widespread application is frequently hindered by unpredictable technique survival and limited peritoneal membrane longevity. Traditionally, the use of PD has depended on the consideration of broad macro-clinical factors, including obesity, older age, and previous abdominal surgeries. However, even among patients with similar clinical profiles, identical prescriptions can exhibit divergent clinical outcomes, indicating that macroscopic indicators alone may not fully account for the inter-individual variability in peritoneal transport. This review represents a comprehensive attempt at precision PD by deconstructing inter-individual variability across a multi-dimensional framework. We systematically explore the factors dictating peritoneal function, transitioning from macroscopic physical constraints such as individualized optimal volume and intraperitoneal pressure; dynamic physiological responses, including microvascular perfusion and lymphatic absorption; to foundational microscopic and genetic determinants such as aquaporin 1 variants and genetic polymorphisms. By integrating the available information across these physical, physiological, and molecular levels, we elucidate the mechanisms driving distinct clinical trajectories and provide a mechanistic basis for understanding inter-individual heterogeneity. This comprehensive understanding of the peritoneal membrane may successfully identify ESRD populations most likely to benefit from PD, thereby promoting the sustainable application of PD.
Reference Key
openalex_W7214317077 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yi Lv, Chunmei Liang, Yuqin Wang, Huanhuan Cao, Chun Zhang, 汪玉梅, Huajun Jiang
Are you one of these authors? Claim your profile
Journal clinical kidney journal
Year 2026
DOI
10.1093/ckj/sfag331
URL
https://doi.org/10.1093/ckj/sfag331
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.