Early-onset colorectal cancer in Sweden: increase in distal tumors but a shift in right-sided incidence, 2020–2024
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ID: 329701
2026
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Abstract
Early-onset colorectal cancer (EOCRC; age <50 years) has increased in high-income countries. We updated a nationwide Swedish cohort study with data from 2020-2024 to compare recent trends with those reported during 1993-2019. Using the National Cancer Register, we identified all incident EOCRC at ages 20-49 years. Temporal trends in age-standardized incidence were assessed using segmented Poisson regression with a breakpoint at 2020 to estimate annual percentage changes (APCs). A total of 1,616 EOCRC cases were diagnosed during 2020-2024. APCs for left-sided colon and rectal cancers were consistent with continued increases in incidence. In contrast, right-sided colon cancer showed a significant change in trend (P = 0.01), with a non-significant decline during 2020-2024 (APC -3.48, 95% CI - 7.88-1.14). These findings indicate that the continued rise in EOCRC is primarily driven by distal tumors, i.e., left-sided colon and rectal cancers. Continued surveillance is needed to clarify long-term patterns and underlying drivers.
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| Reference Key |
openalex_W7214177877
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|---|---|
| Authors | Shabane Barot, Cecilia Radkiewicz |
| Journal | jnci cancer spectrum |
| Year | 2026 |
| DOI |
10.1093/jncics/pkag097
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| URL | |
| Keywords | Keywords not found |
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