Gene identification of L-alanine-3-formylquinuclidine aminotransferase from Brevibacterium aurantiacum NBRC 12171

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ID: 329656
2026
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Abstract
Abstract Quinuclidine derivatives are promising pharmaceutical agents. Herein, we screened for microorganisms capable of converting 3-formylquinuclidine and found that Brevibacterium aurantiacum NBRC 12171 converted 3-formylquinuclidine into quinuclidin-3-ylmethanamine. Through enzyme purification and the heterologous expression of candidate genes, the L-alanine-3-formylquinuclidine aminotransferase gene was identified. Using purified recombinant L-alanine-3-formylquinuclidine aminotransferase, we identified L-alanine as an amino donor for the conversion of 3-formylquinuclidine to quinuclidin-3-ylmethanamine. These findings provide a potential biocatalytic approach for the sustainable production of quinuclidine-based pharmaceutical building blocks.
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Authors Yuki Okumura, Hiroyuki Jomen, Michiki Takeuchi, Shoko Kozono, Ryotaro Hara, Tomotsune Onaga, Tetsuji Noda, Seiichiro Matsumoto, Makoto Ueda, Jun Ogawa
Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag143
URL
https://doi.org/10.1093/bbb/zbag143
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