Cautious Interpretation of the Association Between Topical Corticosteroid Exposure and Type 2 Diabetes

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ID: 329311
2026
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Abstract
Kim et al.'s cohort study on topical corticosteroids (TCS) and incident type 2 diabetes raises three methodological concerns. First, enrollment in 2012 with diabetes ascertainment from 2017 creates a five-year window when outcomes cannot occur, underestimating absolute risk. Second, exposure metrics are redundant (duration derived from prescriptions) and potency groups are pooled; a prescription-count gradient is needed. Third, propensity matching on age and sex ignores disease severity, explaining the spurious protective effect of low-potency TCS; an active comparator within a single indication is recommended.
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Authors Dabin Chen, Yu Liu, Ting Ye
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Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag416
URL
https://doi.org/10.1093/bjd/ljag416
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