Flares and definition of worsening in inflammatory myopathies: a narrative review of the literature

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ID: 329209
2026
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Abstract
Idiopathic inflammatory myopathies (IIM) follow a chronic, polycyclic course in a substantial proportion of patients. Unlike remission, which has recently been standardised, the definition of flare (or worsening) remains highly heterogeneous, creating a divide between clinical trials and real-world practice. Validated core set definitions of worsening exist for trials but were derived by consensus on paper patient profiles and are criticised for inadequate content validity; observational studies instead rely on simplified markers such as enzyme elevation or therapeutic escalation. This review summarises existing definitions, contrasting the IMACS and PRINTO statistical criteria with the variable definitions used in longitudinal cohorts. We examine reported flare rates and predictors, the discordance between global and organ-specific (skin, muscle, lung) worsening, and the lessons offered by flare definitions in other rheumatic and inflammatory diseases. We then propose a multi-domain, treatment-anchored framework intended to bridge statistical rigour and clinical utility.
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openalex_W7213650366 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Maria Rosa Pellico, Mert Öztaş, Latika Gupta
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Journal Lara D. Veeken
Year 2026
DOI
10.1093/rheumatology/keag522
URL
https://doi.org/10.1093/rheumatology/keag522
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