REmotely monitored, Mobile health-supported Multidomain Rehabilitation with High Intensity Interval Training for COVID-19 (REMM-HIIT-CoV): Trial Design and Rationale

Clicks: 22
ID: 329134
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #44 of 103 articles by views in Physical Therapy

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Importance Individuals hospitalized with COVID-19 are at increased risk for prolonged physical, cognitive, and psychosocial impairments. Timely post-acute rehabilitation may reduce these sequelae and accelerate recovery. Objective The objective is to determine whether a REmotely monitored, Mobile health-supported Multidomain Rehabilitation Program incorporating High-intensity Interval Training (REMM-HIIT-CoV) after COVID-19 hospitalization improves functional exercise capacity. Design This study is a multicenter, single-blinded, attention controlled, prospective randomized controlled trial. Setting Five academic medical centers will enroll participants for remotely delivered and monitored rehabilitation. Participants The study will enroll 140 community-dwelling adults discharged within 60 days of COVID-19 hospitalization. Intervention Participants are randomized to either (1) a 12-week, individually tailored, structured and progressive multidomain physical rehabilitation intervention—targeting deficits in balance, mobility, strength, and endurance—delivered via videoconference and remotely monitored using activity trackers and a mobile health application; or (2) an exercise education control group without individualized exercise prescription. Main Outcomes and Measures The primary outcome is functional exercise capacity, measured by 6-minute walk distance at 3 months post-randomization. Secondary outcomes include cardiorespiratory fitness (VO2peak), physical function (Short Physical Performance Battery, 30-second Sit-to-Stand, Grip Strength), frailty (Fried Frailty Index), and cognitive function (Montreal Cognitive Assessment), self-reported quality of life (EQ-5D-5L), functional status (Duke Activity Status Index, Lawton Instrumental Activities of Daily Living), mental health (Hospital Anxiety and Depression Scale), and health-related social needs (Accountable Health Communities Health-related Social Needs Screening Tool). Exploratory outcomes include blood-derived biomarkers of inflammation and mitochondrial function, and ultrasound measures of lower extremity skeletal muscle structure. Conclusions REMM-HIIT-CoV is the first randomized trial to evaluate a remotely delivered, structured, and tailored multidomain rehabilitation program incorporating HIIT in post-hospitalized COVID-19 survivors. Relevance Findings may inform evidence-based guidelines and policy-relevant models for home-based remote rehabilitation after severe respiratory infections.
Reference Key
openalex_W7213496377 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ashley Artese, Kirby P. Mayer, Megan Beyer, Marjan Cobbaert, E Wesley Ely, Heath Gasier, Matthew F. Mart, Jeroen Molinger, Brenda T. Pun, Onur M Orun, Rameela Raman, Anthony D. Sung, Paul E. Wischmeyer, Amy M. Pastva, for the REMM-HIIT-CoV Investigative Team
Journal Physical Therapy
Year 2026
DOI
10.1093/ptj/pzag093
URL
https://doi.org/10.1093/ptj/pzag093
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.