Periorbital purpura and macroglossia in immunoglobulin light-chain amyloidosis

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ID: 328970
2026
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Abstract
A 59-year-old man presented with waxy papulonodules and plaques involving his face and oral cavity, accompanied by characteristic periorbital purpura and marked macroglossia. Skin biopsy confirmed Congo red-positive amyloid deposition, and further investigations established immunoglobulin light-chain amyloidosis associated with λ light-chain multiple myeloma. This case highlights the importance of recognizing characteristic mucocutaneous manifestations as a key clue to an underlying plasma cell dyscrasia.
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Authors Yuan Wang, Fang Wang, Yiting Gao, Yue Luo, WenFang Wang, Yongzhuo Wu, Fuqiong Jiang
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Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag288
URL
https://doi.org/10.1093/bjd/ljag288
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