A Multidimensional Assessment of Central Sensitization and Pain in Lipedema: Associations with Sleep and Quality of Life in a Case-Control Study

Clicks: 43
ID: 328933
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #20 of 84 articles by views in regional anesthesia and pain medicine

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
OBJECTIVE: To comprehensively characterize pain in women with lipedema and evaluate its relationship with central sensitization, neuropathic pain characteristics, pain sensitivity, sleep quality, and quality of life. DESIGN: : A cross-sectional controlled study. SETTING: Department of Physical Medicine and Rehabilitation, Ankara Bilkent City Hospital. SUBJECTS: 59 women with Type 2-3, Stage 1-3 lipedema and 59 age-matched healthy controls. METHODS: Pain intensity, neuropathic pain characteristics, symptoms related to central sensitization, pain catastrophizing, sleep quality, health-related quality of life, and pressure pain thresholds were assessed using validated questionnaires and pressure algometry. RESULTS: Compared with healthy controls, women with lipedema had significantly higher pain intensity, painDETECT, Central Sensitization Inventory, pain catastrophizing, and sleep disturbance scores, whereas pressure pain thresholds and all Short Form-36 domain scores were significantly lower (all p < 0.001). Clinically significant symptoms related to central sensitization (Central Sensitization Inventory ≥40) were present in 78.0% of patients versus 8.5% of controls. These associations remained significant after adjustment for age and body mass index. Although pain intensity, painDETECT scores, and pressure pain thresholds were associated with disease stage, Central Sensitization Inventory scores were not. CONCLUSIONS: Pain in lipedema extends beyond local adipose tissue changes and is associated with widespread pain sensitivity, symptoms related to central sensitization, impaired sleep, pain catastrophizing, and reduced quality of life. These findings support a multidimensional approach to pain assessment in lipedema.
Reference Key
openalex_W7213246522 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Berna Orhan, Asli Turan, Sibel Ünsal Delialioğlu, Oyku Isik, Meltem Dalyan
Are you one of these authors? Claim your profile
Journal regional anesthesia and pain medicine
Year 2026
DOI
10.1093/pm/pnag120
URL
https://doi.org/10.1093/pm/pnag120
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.