Inositol hexaphosphate-based neuroinductive hydrogel promotes metabolic-epigenetic signaling to repair spinal cord injury
Clicks: 8
ID: 328771
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
2.1
/100
8 views
7 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #282 of 342 articles by views in national science review
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 342 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Spinal cord injury (SCI) repair is fundamentally constrained by a hostile post-injury microenvironment characterized by oxidative stress, metabolic dysfunction, and aberrant stem cell fate decisions. This study presents a dual-crosslinked neuroinductive hydrogel engineered for the controlled co-release of inositol hexaphosphate (IP6) and magnesium ions (Mg2+). This dynamic-covalent dual-network architecture combines injectability, swelling resistance, and mechanical compliance matched to native spinal cord tissue. Within the 3D matrix, IP6 and Mg2+ are anchored and gradually released via dynamic coordination bonds. Specifically, IP6 functions as a metabolic regulator, triggering AMP-activated protein kinase (AMPK) phosphorylation, elevating intracellular adenosine triphosphate (ATP) levels, and inducing endoplasmic reticulum Ca2+ release. The resulting Ca2+/calmodulin-dependent protein kinase-Ⅱ (CAMKII) cascade promotes phosphorylation and nuclear translocation of the epigenetic coactivator p300, enhances histone acetylation and selectively activates neuron-associated gene expression while suppressing astrocytic differentiation. In parallel, the hydrogel mitigates inflammatory and oxidative stress and supports vascular repair, thereby stabilizing the injury microenvironment to preserve neuroinductive signaling in vivo. Transplantation of the neural stem cell (NSC)-laden hydrogels into a rat SCI model resulted in robust neuronal regeneration, axonal reconnection, and significant recovery of motor and bladder function. This work establishes a metabolically and epigenetically instructive biomaterial strategy for in situ neural regeneration, offering a new paradigm for stem cell-based SCI therapy.
| Reference Key |
openalex_W7213241886
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yang Zhang, Yuan Hu, Yan Xu, Yinan Lin, Jiali Lin, Yisheng Gao, Fuxin Wei, Yahong Zhao, Kunyu Zhang, Liming Bian |
| Journal | national science review |
| Year | 2026 |
| DOI |
10.1093/nsr/nwag600
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.