MiR-23b-3p exerts a protective effect in hypertensive nephropathy by inhibiting fibrosis and inflammation

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ID: 328555
2026
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Abstract
BACKGROUND: This study intends to investigate the correlation between hypertensive nephropathy (HN) and microRNA-23b-3p (miR-23b-3p), and clarify the biological function of miR-23b-3p in renal injury. METHODS: The serum expression levels of miR-23b-3p were compared between HN patients and healthy controls. A mouse model of HN was constructed via persistent Ang II infusion, after which the effects of miR-23b-3p on renal function (ACR/Scr/BUN) were examined. The mRNA levels of renal fibrosis markers (TGF-β1, COL1A1, Fibronectin, α-SMA) and pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in kidney tissues were quantified by RT-qPCR. For in vitro validation, NRK-52E cells were stimulated with Ang II. The interaction between miR-23b-3p and phosphodiesterase 4B (PDE4B) was verified using dual luciferase reporter assay and RNA pull-down assay. RESULTS: In patients with HN, the expression level of miR-23b-3p was positively correlated with eGFR and negatively correlated with ACR. In the mouse model, inhibition of miR-23b-3p exacerbated renal injury; conversely, overexpression of miR-23b-3p exerted a protective effect, which was specifically manifested as decreased levels of ACR, Scr, BUN, fibrotic factors and pro-inflammatory factors. PDE4B is a downstream target gene of miR-23b-3p. The expression trend of PDE4B was opposite to that of miR-23b-3p in HN patients, Ang II-induced mouse models and NRK-52E cells. In NRK-52E cells, PDE4B attenuated the inhibitory effect of miR-23b-3p on fibrotic genes and inflammatory genes. CONCLUSIONS: The pathogenesis of HN is closely associated with the aberrant expression of miR-23b-3p. miR-23b-3p may ameliorate renal tubular fibrosis and inflammatory response via negatively regulating its target gene PDE4B.
Reference Key
openalex_W7212325709 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liang Fan, Cunyou Xiong, Xiujuan Qi
Journal American Journal of Hypertension
Year 2026
DOI
10.1093/ajh/hpag108
URL
https://doi.org/10.1093/ajh/hpag108
Keywords Keywords not found

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