Yeast Strain Development and Process Intensification in High-Gravity Fermentation
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ID: 328490
2026
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Abstract
High- and very-high-gravity (HG/VHG) fermentation increases substrate loading and product titers, thereby improving fermenter utilisation and potentially reducing water use and downstream processing requirements. Initially developed for brewing and fuel ethanol production, these approaches are now applied more broadly in food, beverage, and bioproduct manufacturing. This MiniReview summarises operational definitions and industrial drivers of HG/VHG fermentation and examines the associated constraints in rheology, mass and heat transfer, osmotic and ethanol stress, nutrient availability, and oxidative damage. Yeast improvement strategies are reviewed, including adaptive laboratory evolution, mutagenesis, genome shuffling, multiplex genome editing, non-conventional yeasts, and multi-omics-guided selection. Process developments such as no-cook simultaneous liquefaction, saccharification and fermentation (SLSF), enzyme formulation, nutrient management, and in situ product recovery are considered together with applications in alcoholic beverages, organic acids, microbial lipids, and other value-added products. The review also discusses coproduct valorisation and the need to integrate strain development with process design. Current evidence supports HG/VHG fermentation as a useful process-intensification platform, although performance and sustainability depend strongly on feedstock, operating conditions, product requirements, and the basis used to report fermentation outcomes.
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| Authors | Son Chu-Ky, Tuan‐Anh Pham, Ngoc-Hung Pham, Tien‐Thanh Nguyen, Chinh‐Nghia Nguyen, Tien-Cuong Nguyen, Tuan Le, Thuy-Hang Dam, Lan-Huong Nguyen, Thi Minh Tu Nguyen, Thi Anh-Tuyet Nguyen, Lan-Huong Phung, Quyet‐Tien Phi, Quynh-Anh Pham, Quoc‐Phong Truong, Kien-Cuong Pham, Lương Hùng Tiến, Minh Nhat Dang, Tien-Nam Tien, Joe Eun Son, Sung Keun Jung, Ui Wook Hwang, Soo Rin Kim |
| Journal | fems yeast research |
| Year | 2026 |
| DOI |
10.1093/femsyr/foag046
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| URL | |
| Keywords | Keywords not found |
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