Acute phase reactants in pediatric chronic nonbacterial osteomyelitis: ımplications for diagnosis and correlation with disease phenotype

Clicks: 11
ID: 328121
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #315 of 339 articles by views in Lara D. Veeken

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 339 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
OBJECTIVES: The role of acute phase reactants (APRs) in the diagnosis of chronic nonbacterial osteomyelitis (CNO) is controversial. Many patients have moderate elevation and some have normal levels. Markedly elevated APRs are more likely to have CNO mimickers that cause lower classification scores. This study aims to investigate how elevated APRs affect the classification of CNO at the diagnosis and their relationship with patient and disease characteristics. METHODS: This retrospective single-center study included patients diagnosed with CNO who were grouped according to APRs at diagnosis: markedly elevated APRs (CRP ≥30 mg/L and/or ESR ≥60 mm/hour as proposed by classification criteria) and normal-to-moderately elevated APRs. Clinical and imaging findings, and treatment modalities were compared between groups. RESULTS: Fifty one patients with CNO were included into the study, 31% of them (n = 16) were classified in markedly elevated APRs group. They exhibited lower classification scores and hemoglobin, higher platelet and ferritin concentrations, more extensive involvement of CNO, and a higher likelihood for CNO-associated diseases. Median total number of bone lesions was significantly higher in this group and a moderate correlation was observed between number of bone lesions and CRP. Pelvic bone, clavicle, and sacroiliac joint involvement were significantly more common in patients with markedly elevated APRs. CONCLUSION: Markedly elevated APRs are observed in a substantial subset of CNO patients that may cause classification limitations. These patients show more severe systemic inflammation, more extensive involvement, particularly in clavicle, pelvis, and sacroiliac joints, and a higher likelihood of CNO-associated diseases.
Reference Key
openalex_W7211986977 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Büşra Tetik Dinçer, Pınar Özge Avar-Aydın, Fatma Aydın, Doğacan Sarısoy, Elif Erorhan, Onur Bahçeci, Zeynep Birsin Özçakar
Are you one of these authors? Claim your profile
Journal Lara D. Veeken
Year 2026
DOI
10.1093/rheumatology/keag495
URL
https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keag495/71010807/keag495.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.