A double-blinded randomized controlled pilot study evaluating the efficacy of siRNA inhibiting SPARC microneedle patch versus siRNA inhibiting SPARC and IL4-RA microneedle patch in reducing scar volume

Clicks: 1
ID: 327929
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #331 of 331 articles by views in the british journal of dermatology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 331 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
In a previous randomised intra-individually-controlled clinical trial on early post-surgical scars, we found that dissolvable microneedle patches embedded with small interfering RNA (siRNA) against secreted protein acidic and rich in cysteine (SPARC) (siSPARC) significantly reduced scar volume compared to silicone sheets. The current pilot study builds on the Previous Study and investigates whether dissolvable microneedle patches embedding siRNA against SPARC and IL4-RA (siSPARC+siIL4RA) (Dual-siRNA Therapy) confers further clinical improvement in flattening scars, compared to microneedle patches embedding siSPARC alone (Mono-siRNA Therapy).
Reference Key
openalex_W7211967813 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eleanor Shu Xian Chai, Delwyn Zhi Jie Lim, Xiahong Zhao, Faith N S Y Tan, Yong Yao Chun, Yingrou Tan, Timothy T Y Tan, Hong Liang Tey
Journal the british journal of dermatology
Year 2026
DOI
10.1093/bjd/ljag385
URL
https://doi.org/10.1093/bjd/ljag385
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.