Bowl-shaped Janus mesoporous silica nanomotors: active drug delivery and oxygen modulation for boosting bacterial keratitis treatment

Clicks: 16
ID: 327820
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #335 of 421 articles by views in national science review

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 421 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Bacterial keratitis is a primary cause of corneal blindness, with its clinical treatment hampered by inadequate drug penetration into the deep corneal stroma and the growing emergence of antibiotic resistance. Corneal collagen cross-linking (CXL), a promising non-antibiotic strategy relying on riboflavin (RF) photosensitization and UV-induced stromal stiffening, is limited by poor bioavailability and diminished efficacy in infection-induced hypoxic microenvironments. Herein, we fabricate a self-propelled nanomotor system based on bowl-shaped Janus mesoporous SiO2 nanoparticles via ZIF-8-templated in situ masking, for active ocular drug delivery and spatiotemporal oxygen modulation. The nanomotors possess an open hemispherical architecture with abundant mesopores for efficient RF loading; catalase (CAT) is asymmetrically anchored on their outer surface via regioselective functionalization, forming a Janus structure that enables spatially controlled catalysis and directional propulsion. In antibiotic-resistant lesions, CAT catalyzes endogenous H2O2 to generate O2, driving autonomous nanomotor motion while alleviating hypoxia. This propulsion boosts trans-corneal penetration and stromal drug delivery, and sustained RF release combined with localized oxygenation restores CXL efficacy under hypoxia. This work thus presents a microenvironment-responsive nanoplatform with well-defined structure that integrates active drug delivery and oxygen modulation, overcoming key therapeutic barriers in bacterial keratitis and holding great translational potential for precision ocular nanomedicine.
Reference Key
openalex_W7211968711 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Minchao Liu, Huifang Ren, Yating Zhan, Dewei Li, Jia Jia, Yufang Kou, Hongyue Yu, Tiancong Zhao, Qingjun Zhou, Hengrui Zhang, Xiaomin Li, Lixin Xie
Are you one of these authors? Claim your profile
Journal national science review
Year 2026
DOI
10.1093/nsr/nwag578
URL
https://doi.org/10.1093/nsr/nwag578
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.