The underappreciated role of rifampin in shaping the epidemiology of RT027-like Clostridioides difficile lineages

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ID: 327694
2026
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Abstract
Abstract The global emergence and dissemination of epidemic Clostridioides difficile ribotype 027 (RT027) and related lineages illustrate the role of antimicrobial pressure in shaping the epidemiology of this pathogen. We propose a hierarchical model in which fluoroquinolones (FQs) served as the dominant selective force underlying the worldwide expansion of RT027-related strains, with rifampin and rifamycins acting as secondary modifiers that promoted persistence and regional dominance.
Reference Key
openalex_W7208761273 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Isabella A. Tickler, Richard V. Goering, Fred C. Tenover
Journal The Journal of antimicrobial chemotherapy
Year 2026
DOI
10.1093/jac/dkag310
URL
https://doi.org/10.1093/jac/dkag310
Keywords Keywords not found

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