Baseline disease activity index and forced vital capacity predict clinically meaningful complications and mortality in systemic sclerosis

Clicks: 20
ID: 327684
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #121 of 339 articles by views in Lara D. Veeken

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 339 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
OBJECTIVE: To evaluate whether the modified disease activity index (mDAI) predicts subsequent disease progression and organ damage in systemic sclerosis (SSc). METHODS: We analyzed 227 patients diagnosed with SSc who were enrolled in a prospective SSc registry. Baseline disease activity was assessed using the mDAI; with active disease being defined as an mDAI ≥ 2.5. The primary outcome was a composite of disease-related clinically meaningful complications-based on revised CRISS step 1 events (interstitial lung disease progression, precapillary pulmonary hypertension, scleroderma renal crisis, heart failure, severe digital ischemia, or severe gastrointestinal dysfunction)-or all-cause mortality. Associations were examined using Cox proportional hazards models. RESULTS: At baseline, 42 (18.5%) had active disease. During a median follow-up period of 38 months, 45 (19.7%) patients had experienced the primary outcome. Active disease was associated with a higher risk of events (log-rank p < 0.001). In multivariable analysis, baseline active disease (HR 2.21, 95% CI 1.06-4.59) and a lower forced vital capacity (HR 0.98 per %, 95% CI 0.96-0.99) independently predicted adverse outcomes. Results were consistent across sensitivity analyses using alternative endpoint definitions. CONCLUSION: Baseline mDAI and forced vital capacity independently predict disease-related clinically meaningful complications and mortality in SSc. The mDAI provides a simple, feasible tool for risk stratification beyond progression of interstitial lung disease.
Reference Key
openalex_W7208790219 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tsai‐Hung Yen, Yohei Isomura, Mikito Suzuki, Wen-Nan Huang, Masataka Kuwana
Are you one of these authors? Claim your profile
Journal Lara D. Veeken
Year 2026
DOI
10.1093/rheumatology/keag481
URL
https://doi.org/10.1093/rheumatology/keag481
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.