24-hour Blood Pressure Variability and Falls Among Older Adults with Hypertension Taking Antihypertensive Medication: Results from the AMBROSIA Study

Clicks: 4
ID: 327639
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #65 of 66 articles by views in American Journal of Hypertension

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract BACKGROUND Higher short-term blood pressure (BP) variability (BPV) can reflect impaired autonomic regulation of BP in response to postural change and physical activity, which could precipitate falls through transient cerebral hypoperfusion and loss of postural stability. We hypothesized that higher short-term BPV assessed by ambulatory BP monitoring (ABPM) would be associated with an increased risk of falls. METHODS This prospective study examined the association between BPV assessed by ABPM and fall risk among community-dwelling adults aged ≥65 years with hypertension who were taking antihypertensive medication. Participants completed 24-hour ABPM; subsequently, they completed 12 monthly falls calendars. Systolic BPV was quantified as the standard deviation (SD) of 24-hour systolic BP (SBP) (SD24h-SBP), calculated from the weighted average of awake and asleep SD values. Cox proportional hazards models estimated hazard ratios (HRs) for time to first fall, comparing quartile 4 (Q4) with quartiles 1-3 (Q1-Q3) of SD24h-SBP. RESULTS Among 608 participants (mean±SD age 74.6±6.2 years; 56.9% female), 238 (39.1%) reported a fall during the 12-month follow-up period. Falls occurred in 172/457 (37.6%) and 66/151 (43.4%) participants in Q1-Q3 and Q4 of SD24h-SBP, respectively. Participants in Q4 of SD24h-SBP did not have a higher fall risk than Q1-Q3 (adjusted HR [95% CI] 1.17 [0.86-1.58]). In analyses using the SDs of awake and asleep SBP, Q4 was not associated with fall risk compared with Q1-Q3. CONCLUSION Twenty-four hour and awake BPV assessed by ABPM was not associated with fall risk among older adults taking antihypertensive medication.
Reference Key
openalex_W7208755587 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Keisuke Narita, Rong Wei, Teresa N Harrison, Kimberly Cannavale, Lei Qian, C Barrett Bowling, Paul Muntner, Joseph E. Schwartz, John J. Sim, Daichi Shimbo, Kristi Reynolds
Journal American Journal of Hypertension
Year 2026
DOI
10.1093/ajh/hpag110
URL
https://doi.org/10.1093/ajh/hpag110
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.