Biomimetic sebum organogel enhances cell membrane fluidity for scarless wound healing

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ID: 327523
2026
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Abstract
Abstract Wound scars impose a substantial clinical burden and aesthetic appearance, affecting millions of individuals globally. Herein, inspired by the physical protection and signal-regulating functions of human sebum, we developed a biomimetic sebum organogel for scarless wound healing. This organogel is composed of calcium phosphotungstate sub-nanowires (PWC) and squalene (Sql)—a natural component of human sebum. The PWC gelatinize Sql with high adhesion force for wound retention and Sql release. The released Sql integrates into the plasma membrane of fibroblasts, where it enhances lipid bilayer fluidity, relieves wound tension by facilitating membrane-associated cytoskeleton adaptation, and subsequently suppresses Yes-associated protein (YAP) activation. Through this mechanism, the biomimetic sebum organogel reduces scar formation and promotes regeneration of skin appendages. Our findings present an accessible strategy for scar prevention and also highlight the regulation of cellular membrane fluidity as a promising target for mitigating fibrotic conditions across a range of diseases.
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Authors Li Yan, Han Wang, Xiuru Ji, Yulian Zeng, Zhi‐Gang Liu, Fan Yang, C.P. Chen, Ni Li, Meng Pan, Xun Wang, Dalong Ni
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Journal national science review
Year 2026
DOI
10.1093/nsr/nwag567
URL
https://doi.org/10.1093/nsr/nwag567
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