OsKish coordinates with Lunapark and RHD3 to maintain the structural stability of endoplasmic reticulum network in rice

Clicks: 19
ID: 327488
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #214 of 379 articles by views in The Plant cell

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 379 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The endoplasmic reticulum (ER) is the largest intracellular membrane-bound organelle in eukaryotic cells, comprising an interconnected network of tubules and sheets. Lunapark (LNP) functions as an E3 ubiquitin ligase that targets RHD3, a dynamin-like GTPase essential for homotypic fusion of ER tubules, for proteasomal degradation, thereby modulating ER tubule stability. However, the regulatory mechanism governing LNP activity remains largely unknown. Here, we report the characterization of the rice oskish mutant, which exhibits aberrant aggregation of ER tubules and defective ER exit of seed storage proteins. OsKish is an ER-localized small protein that physically interacts with both OsLNPs and RHD3-like (RHD3L) protein. OsKish stabilizes OsLNPs by suppressing their auto-ubiquitination; concomitantly, OsKish attenuates the membrane fusion activity of RHD3L possibly by inhibiting its oligomerization. Altogether, our studies propose an OsKish-OsLNPs-RHD3L framework for fine-tuning homotypic ER tubule fusion in rice, providing mechanistic insights into the maintenance of ER architecture in plants.
Reference Key
openalex_W7207745834 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pengcheng Zhang, Yihua Wang, Yun Zhu, Yu Zhang, Xiaohang Han, Yu Chen, Jianing Zhang, Bingke Luo, Xiuhao Bao, Hongming Wu, Fan Wang, Ao Zhang, Cailin Lei, Xin Wang, Zhijun Cheng, Chao Li, Yuqiang Liu, Haiyang Wang, Yulong Ren, Jianmin Wan
Are you one of these authors? Claim your profile
Journal The Plant cell
Year 2026
DOI
10.1093/plcell/koag260
URL
https://doi.org/10.1093/plcell/koag260
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.