ntSynt-viz: Visualizing synteny patterns across multiple genomes

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ID: 327403
2026
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Abstract
Abstract With the explosion of chromosome-scale genome assemblies being generated in recent years, there is vast potential for comparative genomics analyses through detecting multi-genome synteny. While existing tools can detect synteny blocks between multiple genomes, their text-based outputs make it challenging to intuitively explore large-scale synteny patterns. Interpretable, information-rich and easy-to-use synteny visualization tools are imperative to enable important biological insights from the synteny block data output by the aforementioned utilities. Here, we present ntSynt-viz, a command-line tool for automated sorting, normalization and plotting of multi-genome synteny blocks. We show how ntSynt-viz provides clearer and more easily interpretable chromosome-painting ribbon plots compared to the state-of-the-art tool NGenomeSyn when evaluating synteny between 14 human genomes and 9 hoverfly genomes. We expect that ntSynt-viz will provide crucial insights into large-scale synteny patterns between divergent genomes, thereby advancing research into key evolutionary questions. ntSynt-viz is freely available on GitHub ( https://github.com/bcgsc/ntsynt-viz ).
Reference Key
openalex_W4406541932 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lauren Coombe, René L. Warren, İnanç Birol
Journal journal of evolutionary biology
Year 2026
DOI
10.1093/jeb/voag079
URL
https://doi.org/10.1093/jeb/voag079
Keywords Keywords not found

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