Effects of Resistance Training Sets on Cognition and Brain-Derived Neurotrophic Factor in Cognitively Impaired Individuals: A Quasi-Experimental Study

Clicks: 19
ID: 327076
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #108 of 176 articles by views in the journals of gerontology series a, biological sciences and medical sciences

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 176 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: The minimum effective resistance training (RT) volume prescription strategy for individuals with cognitive impairment (CI) remains unclear in the literature. This study compared the effects of single-set (SET1) versus three-set (SET3) RT on global cognition, brain-derived neurotrophic factor (BDNF), and physical performance in individuals with CI. METHODS: The study was formally registered on ClinicalTrials.gov (NCT06185010; V2) and followed the TREND guidelines. We randomized thirty participants to SET1 (n = 15) or SET3 (n = 15) and nonrandomly allocated thirteen participants to a control group (CON). The 8-week RT program included leg press (40-60% one-repetition maximum [1RM]), chest press (50-70% 1RM), chair squats, and med ball throws. Primary outcomes assessed at baseline and post-intervention included the Dementia Rating Scale-2 (DRS-2), serum BDNF, and the Short Physical Performance Battery (SPPB). Secondary outcomes were creatine kinase (CK) and composite strength (handgrip strength plus 1RM leg and chest press). We analyzed the outcomes using generalized linear mixed models. RESULTS: There were no post-intervention between-group differences for DRS-2 or BDNF, and neither group demonstrated increases from baseline. Physical performance improved in both RT groups compared with CON, with SPPB increasing by 2.7 points in SET1 and 1.4 points in SET3. CK did not change meaningfully. Composite strength did not differ between groups at post-test; however, only SET1 showed a significant increase (+12 kg). CONCLUSION: Both sets improved physical performance but were not associated with detectable changes in cognition or BDNF in individuals with CI. Single-sets may represent an efficient strategy in this population.
Reference Key
openalex_W7204970315 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nuno Fonseca, Dulce Esteves, Diogo Luís Marques, Carla Pais Fonseca, Jorge Costa, Tiago Sousa, Antônio Carlos de Sousa, Henrique P. Neiva, Mikel Izquierdo, Mário Cardoso Marques
Are you one of these authors? Claim your profile
Journal the journals of gerontology series a, biological sciences and medical sciences
Year 2026
DOI
10.1093/gerona/glag216
URL
https://doi.org/10.1093/gerona/glag216
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.