A macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression in KK-Ay mice

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ID: 327059
2026
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Abstract
Macrophage-conditioned medium models are widely used in obesity research, but correspondence with obese animals has not been examined. We compared the effects of Kaempferia parviflora in this model and KK-Ay diabetic obese model mice. Anti-inflammatory effects and restoration of uncoupling protein-1 (UCP-1) expression were observed in both models, indicating that the macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression.
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openalex_W7204948439 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hisako Takahashi, Hiromu Morimoto, Hirofumi Inoue, Kentaro Kaneko, Tsuyoshi Goto, Teruo Kawada, Mariko Uehara, Nobuyuki Takahashi
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Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag133
URL
https://doi.org/10.1093/bbb/zbag133
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