Effectiveness, Patient Satisfaction, and Safety of a Next-generation PLLA Collagen Biostimulator for Nasolabial Fold Augmentation: 12-month Results of a Prospective Multicenter Study

Clicks: 22
ID: 326952
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #68 of 129 articles by views in Aesthetic surgery journal

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 129 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: Poly-L-lactic acid (PLLA) dermal fillers induce neocollagenesis through a bioinductive mechanism rather than facial tissue volumization. The next-generation PLLA-LASYNPRO formulation (LASYNPRO, Lactic Acid Induced Synthesis of Collagen Protein), a biomaterial-microsphere technology developed for regenerative aesthetic biostimulation, composed of uniform, non-porous microspheres, has been proposed as an evolution of earlier PLLA products, offering a more controlled, lower-inflammatory regenerative pathway. Efficacy data for nasolabial fold (NLF) correction are emerging, but patient-reported outcomes remain underreported. OBJECTIVES: To evaluate patient-reported outcomes, aesthetic self-perception, and treatment satisfaction over 12 months following JULÄINE (PLLA-LASYNPRO) treatment for NLF correction. METHODS: Prospective, single-arm, multicenter post-market clinical follow-up (PMCF) investigation enrolling 60 subjects. Subjects received up to 3 bilateral NLF injections of JULÄINE™ at 2- to 4-week intervals. Patient-reported outcomes included FACE-Q Appraisal of Lines (Nasolabial Folds), FACE-Q Satisfaction with Outcome, the Global Aesthetic Improvement Scale (GAIS), and a 12-item subject satisfaction questionnaire, assessed at 6 and 12 months after the final injection. RESULTS: At 12 months, the FACE-Q Appraisal of Lines score improved by a mean of 20.7 points (P<.0001; d=1.14), a large effect that continued to grow between 6 and 12 months. Subject GAIS responder rate was 83.3% at both timepoints. More than 90% of subjects reported natural-looking results; 83%-85% would repeat the treatment; 90%-94% would recommend it. Overall satisfaction was 88.9% at 6 months and 77.8% at 12 months. No serious adverse events or device deficiencies were reported. CONCLUSIONS: JULÄINE produced sustained, clinically meaningful improvements in patient-perceived aesthetic outcomes with high treatment satisfaction over 12 months. The consistent perception of natural-looking results is in line with the progressive, collagen-building mechanism of PLLA-LASYNPRO.
Reference Key
openalex_W7205015526 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Adriana Ribé, Ulrika Erhardt, karina de Almeida Caramico, Émilie Souton-Al Gburi, Franco Grimolizzi, Per Hedén
Are you one of these authors? Claim your profile
Journal Aesthetic surgery journal
Year 2026
DOI
10.1093/asj/sjag180
URL
https://doi.org/10.1093/asj/sjag180
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.