Uridine mitigated Listeria monocytogenes infection in mice by improving gut microbiota and protecting the intestinal barrier

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ID: 326930
2026
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Abstract
Abstract This study investigated the protective effects of uridine against Listeria monocytogenes infection in mice and explored the underlying mechanisms. Uridine markedly suppressed pathogen loads in the liver and spleen, mitigating infection-induced pathological damage. In terms of systemic inflammation, uridine significantly reduced serum levels of IL-6, TNF-α and IL-1β. Moreover, uridine upregulated the mRNA and protein expression of tight junction proteins (ZO-1, Claudin-1, Occludin) and Mucin-2, while inhibiting activation of the myosin light chain kinase (MLCK)-MLC signaling pathway, thus preserving barrier integrity. In addition, uridine increased fecal levels of short-chain fatty acids (SCFAs), particularly propionate and valerate, and modulated gut microbiota composition. Collectively, these findings demonstrate that uridine protects against L. monocytogenes infection by suppressing inflammation, strengthening the intestinal barrier, promoting SCFA production, and modulating the gut microbiota. This work provides important theoretical and experimental evidence supporting the development of uridine-based agents for prevention or mitigation of listeriosis.
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openalex_W7205005244 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ailin Wang, Yunqi Gu, Meihan Zhang, Xiaomeng Ren, Xiaodong Xia
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Journal Food Quality and Safety
Year 2026
DOI
10.1093/fqsafe/fyag065
URL
https://doi.org/10.1093/fqsafe/fyag065
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