Long-term Clinical Outcomes of Autologous Non-activated Platelet-rich Plasma (A-PRP) Delivered Through Mechanical and Controlled Infiltration in Male and Female Androgenetic Alopecia: A 10-year Prospective Randomized Evaluator-blinded Study

Clicks: 84
ID: 326898
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #13 of 129 articles by views in Aesthetic surgery journal

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 129 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: Androgenetic alopecia (AGA) is the most common cause of progressive hair loss in men and women and is associated with significant psychosocial distress. Platelet-rich plasma (PRP) is a regenerative therapy that stimulates follicular activity, angiogenesis, and dermal papilla activation through growth factor release. OBJECTIVES: This prospective randomized evaluator-blinded clinical trial evaluated the long-term efficacy and safety of autologous non-activated PRP (A-PRP) delivered through a standardized mechanical and controlled infiltration protocol. METHODS: Between January 2015 and January 2025, 234 patients with AGA were enrolled, including 135 men (Norwood-Hamilton I-IV) and 99 women (Ludwig I-II); 25 patients had previous confirmed COVID-19 infection. Patients received three A-PRP sessions at 30-day intervals with intradermal administration of 0.2 mL/cm2. Hair density (HD), hair thickness (HT), and total hair count (HC) were assessed by computerized trichoscopy and phototrichogram analysis at baseline, 12, 36, 60, and 120 months. RESULTS: At 12 months, HD increased by 31.4%, HT by 26.8%, and HC by 29.7% compared with baseline (p < 0.001). HD remained above baseline at 36 months (+24.1%) and 60 months (+17.3%). At 120 months, patients receiving maintenance treatment showed an 11.2% improvement. Female patients demonstrated greater preservation of hair shaft diameter. No significant differences were observed according to previous COVID-19 infection, and no severe adverse events occurred. CONCLUSIONS: Standardized A-PRP infiltration provides a safe and effective regenerative approach for AGA, with maintained clinical improvement during long-term follow-up. These findings support the role of standardized delivery protocols in improving reproducibility and therapeutic consistency in regenerative hair restoration.
Reference Key
openalex_W7204990794 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pietro Gentile
Are you one of these authors? Claim your profile
Journal Aesthetic surgery journal
Year 2026
DOI
10.1093/asj/sjag181
URL
https://doi.org/10.1093/asj/sjag181
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.