Timing of mental disorders in relation to cancer-specific mortality in cancer patients

Clicks: 21
ID: 326739
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #134 of 408 articles by views in JNCI Journal of the National Cancer Institute

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 408 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
BACKGROUND: To evaluate whether mental disorders identified before cancer diagnosis, within one year, or 2-5 years after cancer diagnosis are associated with cancer-specific mortality, and whether having both pre- and post-diagnosis disorders displays the highest mortality. METHODS: We conducted a cohort study of 22,281 UK Biobank participants linked to cancer and death registries. Mental disorders were ascertained from inpatient and outpatient diagnoses and psychiatric prescriptions, then categorized by period. We applied period-specific longitudinal inverse probability weighting to preserve early-period information and estimate time-specific effects, with treatment and death censoring weights to reduce confounding and survival bias. Weighted Cox models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) overall and by site (prostate, breast, colorectal, lung, and lymphoma). Additional models evaluated pre-only, post-only, and both pre- and post-diagnosis disorders versus none. RESULTS: Over median 5.3 year follow-up, 6,134 cancer-specific deaths occurred. Mental disorders were associated with higher overall cancer mortality: pre-diagnosis (HR [95% CI]: 1.19 [1.11,1.27]), first year post-diagnosis (1.38 [1.26,1.51]), and years 2-5 (2.19 [1.97,2.43]). Associations were strongest and most consistent during years 2-5 across sites (HRs, 1.58-2.27). Site-specific analyses additionally showed elevated hazards for pre-diagnosis and first-year disorders in lymphoma and first-year disorders in colorectal cancer. Patients with post-diagnosis mental disorders, regardless of pre-diagnosis status, had higher cancer mortality than those with pre-diagnosis disorders only or none. CONCLUSION: Mental disorders were associated with cancer-specific mortality throughout the continuum, with the strongest associations in years 2-5 across multiple sites. Findings support routine mental-health screening and intervention in survivorship care.
Reference Key
openalex_W7204461128 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mingyi Li, Zhengyi Deng, Minji Jung, Kevin L'Espérance, Michael Baiocchi, David Spiegel, Benjamin I Chung, Marvin Epolian Langston, Melissa L. Bondy
Are you one of these authors? Claim your profile
Journal JNCI Journal of the National Cancer Institute
Year 2026
DOI
10.1093/jnci/djag289
URL
https://doi.org/10.1093/jnci/djag289
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.