Maternal Tributyltin Exposure Is Associated With Male-Biased Immune Dysregulation Across Generations
Clicks: 13
ID: 326520
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
3.6
/100
13 views
12 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #219 of 308 articles by views in american journal of physiology endocrinology and metabolism
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 308 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Tributyltin (TBT) is an environmental obesogen and endocrine-disrupting chemical that promotes adipogenesis and transgenerational metabolic dysfunction in mice. Although developmental TBT exposure has been linked to male-biased adiposity, insulin dysregulation, and hepatic pathology, its effects on the immune system remain unclear. We investigated whether maternal TBT exposure is associated with persistent immune dysregulation in F1 and F3 offspring. Peripheral blood immunophenotyping data generated by the German Mouse Clinic were reanalyzed in F1 offspring of control- and TBT-exposed dams. Maternal TBT exposure was associated with increased B-cell representation, reduced T-cell representation, an altered B-cell-to-T-cell balance, a reduced CD4/CD8 ratio, and decreased NK-cell frequencies. We then analyzed splenic immune-marker expression and circulating inflammatory cytokines in an independent transgenerational cohort. In F1 males, TBT exposure was associated with reduced expression of T-cell- and myeloid-associated markers and increased expression of inflammatory cytokines. Similar changes were observed in unexposed F3 male descendants of the TBT lineage, whereas F3 females showed no significant changes in the immune markers examined. Plasma TNF and IL-6 were increased in F1 and F3 males but not females. These findings identify the immune system as a potential target of developmental obesogen exposure and support a persistent, male-biased immune phenotype characterized by altered splenic immune-marker expression and elevated inflammatory cytokines across generations.
| Reference Key |
openalex_W7204244043
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Richard Chang, Michelle Avila, Yikai Huang, Kaitlin To, Juan Antonio Aguilar‐Pimentel, Thure Adler, Valérie Gailus‐Durner, Helmut Fuchs, Martin Hrabě de Angelis, Bruce Blumberg |
| Journal | american journal of physiology endocrinology and metabolism |
| Year | 2026 |
| DOI |
10.1210/endocr/bqag097
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.